Researchers have found many uses for MALDI mass spectrometry imaging in the process of drug development:
Visualizing the effects of new therapies by determining the precise distribution of drugs and drug metabolites in a tissue section
Potential target identification of compounds in therapeutic pathways by comparing the biomolecular composition of healthy and diseased tissues
Optimizing drug delivery mechanisms
Predicting or understanding the mechanism of action of a drug’s toxicity
For pharmaceutical research and development, experimental protocols must be reproducible, robust, and easy-to-use. The proprietary spray technology of the HTX TM-Sprayer and M5 Sprayer guarantees a very fine, uniform, and consistent matrix coating crucial for high-resolution imaging and relative quantification of analytes.
HTX Application Note #42
MALDI IMS can allow a better understanding of the molecular and cellular processes underlying the pathologic findings in pre-clinical drug development that could enable scientists to better anticipate and predict human risk and response to a candidate pharmaceutical. In the present study, we aimed to investigate the potential age sensitivity to dabrafenib-induced renal toxicity.
HTX Application Note #47